| 名稱 | c-Kit D816H/BaF3 |
| 型號 | CBP73282 |
| 報價 |  |
| 特點 | c-Kit D816H/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO；KIT D816H 位于 Kit 蛋白（PMID：19164557）的酪氨酸激酶結構域區域 2（外顯子 17）內。 D816H 導致激酶活性增加、組成型 Kit 磷酸化、Stat3 信號傳導激活和培養細胞轉化，并賦予對某些 Kit 抑制劑的抗性。 |
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藥靶細胞株 > kinase激酶細胞株 > CBP73282c-Kit D816H/BaF3
- 詳細內容
CBP73282 | |
| I. Introduction | |
Cell Line Name： | c-Kit D816H/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
KIT D816H lies within the tyrosine kinase domain region 2 (exon 17) of the Kit protein (PMID: 19164557). D816H results in increased kinase activity, constitutive Kit phosphorylation, activation of Stat3 signaling, and transformation of cultured cells (PMID: 10362788, PMID: 11494148), and confers resistance to some Kit inhibitors (PMID: 25239608). | |
| III. Representative Data | |
1. WB of c-Kit D816H/BaF3
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2. Sanger of c-Kit D816H/BaF3
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3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 C-KlT D816H. | |
