| 名稱 | c-Kit D816Y/BaF3 |
| 型號 | CBP73276 |
| 報價 |  |
| 特點 | c-Kit D816Y/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO；KIT D816Y 位于 Kit 蛋白的酪氨酸激酶結(jié)構(gòu)域 2 內(nèi)（PMID：21640708）。 D816Y 導(dǎo)致 Kit 的組成型磷酸化，激活培養(yǎng)細胞中的 Akt 和 Mapk 通路（PMID：21640708，PMID：16397263），并在培養(yǎng)中對伊馬替尼產(chǎn)生抗性（PMID：16397263）。 |
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藥靶細胞株 > kinase激酶細胞株 > CBP73276c-Kit D816Y/BaF3
- 詳細內(nèi)容
CBP73276 | |
| I. Introduction | |
Cell Line Name： | c-Kit D816Y/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
KIT D816Y lies within the tyrosine kinase domain 2 of the Kit protein (PMID: 21640708). D816Y results in constitutive phosphorylation of Kit, activation of Akt and Mapk pathways in cultured cells (PMID: 21640708, PMID: 16397263), and confers resistance to imatinib in culture (PMID: 16397263). | |
| III. Representative Data | |
1. WB of c-Kit D816Y/BaF3
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2.Sanger of c-Kit D816Y/BaF3
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3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 c-KIT D816Y (C1). | |
