久在草_国产精品久久久久久久久免费樱桃_欧美婷婷色_日韩成人在线影院_永久免费精品视频_欧美精品免费一区欧美久久优播

加入收藏 | 設(shè)為首頁 | 聯(lián)系我們

產(chǎn)品搜索

產(chǎn)品分類

聯(lián)系我們

聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： [email protected]

產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73194ETV6-NTRK3/BaF3

ETV6-NTRK3/BaF3
名稱 ETV6-NTRK3/BaF3
型號 CBP73194
報價
特點(diǎn) ETV6-NTRK3/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容


CBP73194

I. Introduction

Cell Line Name：

ETV6-NTRK3/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+1 ug/ml puromycin

Mycoplasma Status:

Negative


II.Background
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25) fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes for an chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain of the NTRK3 protein. The ETV6 gene codes for the transcription factor protein, ETV6, which suppresses the expression of, and thereby regulates, various genes that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network. NTRK3 codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma.

III. Representative Data

1. WB of  ETV6-NTRK3/BaF3 expression

CBP73194 WB.jpg

2. Anti-proliferation assay

CBP73194 fig.png

Figure 2. Anti-proliferation assay of two reference compounds on the ETV6-NTRK3/BaF3 Stable Cell Line



如果你對CBP73194ETV6-NTRK3/BaF3感興趣，想了解更詳細(xì)的產(chǎn)品信息，填寫下表直接與廠家聯(lián)系：


留言框

  • 產(chǎn)品：

  • 您的單位：

  • 您的姓名：

  • 聯(lián)系電話：

  • 常用郵箱：

  • 省份：

  • 詳細(xì)地址：

  • 補(bǔ)充說明：

  • 驗證碼：

    請輸入計算結(jié)果（填寫阿拉伯?dāng)?shù)字），如：三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
主站蜘蛛池模板： www.伊人 | 久久精品视频在线观看 | 欧美一级电影网 | 91高清在线观看 | 免费看h网站| 国产成人精品一区二区在线 | 免费在线观看黄 | 91国视频在线 | 久久国产a | 亚洲综合国产 | 亚洲国产日本 | 欧美 video | 欧美福利专区 | 天天操天天摸天天爽 | 中国明星一级毛片免费 | 亚洲色图综合图片 | 一区二区三区视频在线 | 97丨九色丨国产人妻熟女 | 一级一级毛片免费看 | 奇米视频在线 | 欧美成人久久久 | 亚洲欧洲另类 | 9191在线 | 国产精品久久久久无码av | 欧美在线亚洲 | 日韩欧美精品一区 | 国产欧美日韩综合精品一区二区 | 国产精品亚洲综合 | www国产视频| 免费的色网站 | yy4138理论片在线大全 | 成人午夜电影网 | 国产午夜精品一区二区三区在线观看 | 国产日韩欧美一区 | 欧美日韩国产一区二区三区 | 久久97久久97精品免视看 | 伊人激情网 | 久久久久日韩精品免费观看网 | 九九免费在线视频 | 亚洲欧美成人 | 免费区一级欧美毛片 |