| 名稱 | CD112/TCR Activator/CHO |
| 型號 | CBP74121 |
| 報價 |  |
| 特點 | CD112/TCR Activator/CHO，凍存條件：90% FBS+10% DMSO |
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- 詳細內容
| I. Background | |
PVRIG（CD112R），是脊髓灰質炎病毒受體(PVR)家族的共抑制受體，在自然殺傷細 胞（NK）和 T 細胞上表達。它與其配體（CD112 或 PVRL2/nectin-2）結合，抑制 T 細胞和 NK 細胞對癌癥的反應。因此，CD112R 作為一種新的免疫檢查點抑制劑在癌癥治療 具有很高的潛力。 | |
| II. Description | |
CD112 TCR Activator CHO 細胞作為 PVRIG(CD112R) Effector Reporter Cell 的靶細胞， 很好的模擬了體內 PVRIG(CD112R) 的信號轉導過程，原理見下圖所示。
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| III. Introduction | |
| Expressed gene: | CD112 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Nectin-2, Herpes virus entry mediator B, HVEB, PVRL2, and PRR2 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+600μg/ml hygromycin+2μg/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
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| IV. Representative Data | |
Figure 2. Recombinant CHO-cells constitutively expressing CD112. | |
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Figure 3. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cell(C7) With CD112/TCR Activator - CHO Cells. | |
