| 名稱 | EGFR p.E746_A750delELREA Reference Standard 標準品 |
| 型號 | CBP10334 |
| 報價 |  |
| 特點 | EGFR p.E746_A750delELREA Reference Standard |
產品搜索
相關文章
聯系我們
產品展示 / PRODUCTS
- 詳細內容
CBP10334 | |
| Format | Genomic DNA |
| Description | EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750 (PMID: 17318210). E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models (PMID: 16373402, PMID: 16912195), and is transforming in cell culture (PMID: 29533785). |
| Technical Data | |
| DNA Change | c.2235_2249del15 GGAATTAAGAGAAGC>- |
| AA Change | p.E746_A750delELREA |
| Mutation type | Deletion - In frame |
| Zygosity | Heterozygous |
| Allelic Frequency | 88.9% |
| Transcript | ENST00000275493 |
| Cosmic ID | COSM6223 |
| Chr position(GRCh37) | chr7:55242465_55242479 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
" _ue_custom_node_="true">
