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Cell Line Name：

EGFR S768_V769delinsIL(S768I&V769L)/BaF3

Host Cell:

Ba/F3

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

Complete Culture Medium:

Mycoplasma Status:

Negative

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019).

1. WB of EGFR S768_V769delinsIL(S768I&V769L)/BaF3

2. Anti-proliferation assay